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Premiered at the 2001 Toronto International Film Festival, the film received a DVD release in 2005.
She appeared as a hospital administrator in the thriller John Q, about a father and husband (Denzel Washington) whose son is diagnosed with an enlarged heart.
Her Catherine is a case of arrested development, impatient, aggressively indignant, impulsive".
In 2004, Heche received a Primetime Emmy Award nomination for Best Supporting Actress for her performance in the Lifetime movie Gracie's Choice, as well as a Saturn Award nomination for Best Actress for her performance in the CBS television film The Dead Will Tell.
Sterling in the film adaptation of Elizabeth Wurtzel's autobiography about depression, Prozac Nation, with Christina Ricci and Jessica Lange.She made her TV-movie debut the following year with a brief appearance in the Hallmark Hall of Fame presentation of O Pioneers! In 1993, Heche made her feature-film debut in Disney's The Adventures of Huck Finn with Elijah Wood.Over the next two years, she had small supporting roles in made-for-TV movies such as Girls in Prison (1994) and Kingfish: A Story of Huey P. She also appeared in the straight-to-video erotic thriller Wild Side (1995) as Joan Chen's lesbian lover.In the same year, she acted opposite Alec Baldwin in Broadway's Twentieth Century, about a successful and egomaniacal Broadway director (Baldwin), who has transformed a chorus girl (Heche) into a leading lady.For her performance, she was nominated for the 2004 Tony Award for Best Actress in a Play.